The Modulating Effect of Perfluorane on the Ratio of Pro- to Antioxidative Systems in Different Organs

Abstract

The experiment demonstrated the modulating effect of the antihypoxic agent perfluorane, a blood substitute having multifunctional properties, on the ratio of pro- to antioxidative systems in different organs. In the heart, perfluorane prevented the activation of free radical oxidation under stress, by increasing the activity of superoxide dismutase (SOD) and other enzymes of antioxidative defense. In the liver less resistant to free radical tissue oxidation, acute stress lowered the activity of SOD by 37% during administration of perfluorane, which was followed by the unchanged baseline level of oxidation products and by the hypersensitivity of membranous structures to induction of free radical oxidation. Under stress, proxanol in the heart and liver protected membranous structures from the influence of APK-induced damaging factors without substantially activating the enzymes of antioxidative defense. It is concluded that it is necessary to choose the optimum dosage of the drugs modulating the ratio of pro- to antioxidants in the cell, by taking into account the state of organs that are most sensitive to active oxygen forms.

Keywords

• perfluorane
• proxanol
• stress
• free radical oxidation
• antioxidative enzymes