Adipose Stromal/Stem Cell-Derived Extracellular Vesicles: Potential Next-Generation Anti-Obesity Agents

Mariachiara Zuccarini; Patricia Giuliani; Valentina Di Liberto; Monica Frinchi; Francesco Caciagli; Vanni Caruso; Renata Ciccarelli; Giuseppa Mudò; Patrizia Di Iorio

doi:10.3390/ijms23031543

International Journal of Molecular Sciences (Jan 2022)

Adipose Stromal/Stem Cell-Derived Extracellular Vesicles: Potential Next-Generation Anti-Obesity Agents

Mariachiara Zuccarini,
Patricia Giuliani,
Valentina Di Liberto,
Monica Frinchi,
Francesco Caciagli,
Vanni Caruso,
Renata Ciccarelli,
Giuseppa Mudò,
Patrizia Di Iorio

Affiliations

Mariachiara Zuccarini: Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Via dei Vestini 29, 66100 Chieti, Italy
Patricia Giuliani: Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Via dei Vestini 29, 66100 Chieti, Italy
Valentina Di Liberto: Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, 90128 Palermo, Italy
Monica Frinchi: Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, 90128 Palermo, Italy
Francesco Caciagli: Center for Advanced Studies and Technologies (CAST), University of Chieti-Pescara, Via L. Polacchi, 66100 Chieti, Italy
Vanni Caruso: School of Pharmacy and Pharmacology, University of Tasmania, Hobart 7001, Australia
Renata Ciccarelli: Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Via dei Vestini 29, 66100 Chieti, Italy
Giuseppa Mudò: Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, 90128 Palermo, Italy
Patrizia Di Iorio: Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Via dei Vestini 29, 66100 Chieti, Italy

DOI: https://doi.org/10.3390/ijms23031543
Journal volume & issue: Vol. 23, no. 3
p. 1543

Abstract

Read online

Over the last decade, several compounds have been identified for the treatment of obesity. However, due to the complexity of the disease, many pharmacological interventions have raised concerns about their efficacy and safety. Therefore, it is important to discover new factors involved in the induction/progression of obesity. Adipose stromal/stem cells (ASCs), which are mostly isolated from subcutaneous adipose tissue, are the primary cells contributing to the expansion of fat mass. Like other cells, ASCs release nanoparticles known as extracellular vesicles (EVs), which are being actively studied for their potential applications in a variety of diseases. Here, we focused on the importance of the con-tribution of ASC-derived EVs in the regulation of metabolic processes. In addition, we outlined the advantages/disadvantages of the use of EVs as potential next-generation anti-obesity agents.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

About the journal

Abstract

Keywords