Communications Biology (Jan 2023)

Self-recycling and partially conservative replication of mycobacterial methylmannose polysaccharides

  • Ana Maranha,
  • Mafalda Costa,
  • Jorge Ripoll-Rozada,
  • José A. Manso,
  • Vanessa Miranda,
  • Vera M. Mendes,
  • Bruno Manadas,
  • Sandra Macedo-Ribeiro,
  • M. Rita Ventura,
  • Pedro José Barbosa Pereira,
  • Nuno Empadinhas

DOI
https://doi.org/10.1038/s42003-023-04448-3
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 17

Abstract

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The mechanism of methylmannose polysaccharide (MMP) biogenesis in nontuberculous mycobacteria (NTM) is characterized, which involves an MMP-specific hydrolase (MmpH) and a rare mannosyltransferase (ManT). MmpH and ManT structures are presented.