Zebrafish pigment cells develop directly from persistent highly multipotent progenitors

Tatiana Subkhankulova; Karen Camargo Sosa; Leonid A. Uroshlev; Masataka Nikaido; Noah Shriever; Artem S. Kasianov; Xueyan Yang; Frederico S. L. M. Rodrigues; Thomas J. Carney; Gemma Bavister; Hartmut Schwetlick; Jonathan H. P. Dawes; Andrea Rocco; Vsevolod J. Makeev; Robert N. Kelsh

doi:10.1038/s41467-023-36876-4

Nature Communications (Mar 2023)

Zebrafish pigment cells develop directly from persistent highly multipotent progenitors

Tatiana Subkhankulova,
Karen Camargo Sosa,
Leonid A. Uroshlev,
Masataka Nikaido,
Noah Shriever,
Artem S. Kasianov,
Xueyan Yang,
Frederico S. L. M. Rodrigues,
Thomas J. Carney,
Gemma Bavister,
Hartmut Schwetlick,
Jonathan H. P. Dawes,
Andrea Rocco,
Vsevolod J. Makeev,
Robert N. Kelsh

Affiliations

Tatiana Subkhankulova: Department of Life Sciences, University of Bath, Claverton Down
Karen Camargo Sosa: Department of Life Sciences, University of Bath, Claverton Down
Leonid A. Uroshlev: Vavilov Institute of General Genetics, Russian Academy of Sciences
Masataka Nikaido: Department of Life Sciences, University of Bath, Claverton Down
Noah Shriever: Department of Life Sciences, University of Bath, Claverton Down
Artem S. Kasianov: Vavilov Institute of General Genetics, Russian Academy of Sciences
Xueyan Yang: Department of Life Sciences, University of Bath, Claverton Down
Frederico S. L. M. Rodrigues: Department of Life Sciences, University of Bath, Claverton Down
Thomas J. Carney: Department of Life Sciences, University of Bath, Claverton Down
Gemma Bavister: Department of Life Sciences, University of Bath, Claverton Down
Hartmut Schwetlick: Department of Mathematical Sciences, University of Bath, Claverton Down
Jonathan H. P. Dawes: Department of Mathematical Sciences, University of Bath, Claverton Down
Andrea Rocco: Department of Microbial Sciences, FHMS, University of Surrey
Vsevolod J. Makeev: Vavilov Institute of General Genetics, Russian Academy of Sciences
Robert N. Kelsh: Department of Life Sciences, University of Bath, Claverton Down

DOI: https://doi.org/10.1038/s41467-023-36876-4
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 19

Abstract

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Neural crest cells are highly multipotent stem cells, but it remains unclear how their fate restriction to specific fates occurs. Here, the authors show in zebrafish that broad multipotency is retained even after migration, suggesting that fate restriction occurs directly, but dynamically.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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