State of Compensatory-Adaptive Mechanisms in Patients with Purulent Meningitis in Dynamics of the Disease

Abstract

The article analyzes the clinical features of autonomic dysfunction and state of compensatory-adaptive mechanisms in patients with purulent meningitis in the dynamics of the disease. We found that in patients with purulent meningitis at the height of the disease dominance of cerebral, meningeal symptoms combined with some objective evidence of autonomic dysfunction and reduced power of heart rate variability with the presence of autonomic imbalance towards vagotonia. In the dynamics in patients with purulent meningitis against the background of conventional treatment clinical signs of autonomic dysfunction prevail from the 2nd week, they persist at discharge in 72.7 % of patients, combining with imbalanced parameters of neurohumoral regulation, in the form of reduced power of spectral parameters of heart rate variability with presence of autonomic imbalance towards vagotonia.

Keywords

• purulent meningitis
• autonomic dysfunction
• heart rate variability