Nature Communications (Oct 2022)
A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma
- Royce W. Zhou,
- Jia Xu,
- Tiphaine C. Martin,
- Alexis L. Zachem,
- John He,
- Sait Ozturk,
- Deniz Demircioglu,
- Ankita Bansal,
- Andrew P. Trotta,
- Bruno Giotti,
- Berkley Gryder,
- Yao Shen,
- Xuewei Wu,
- Saul Carcamo,
- Kaitlyn Bosch,
- Benjamin Hopkins,
- Alexander Tsankov,
- Randolph Steinhagen,
- Drew R. Jones,
- John Asara,
- Jerry E. Chipuk,
- Rachel Brody,
- Steven Itzkowitz,
- Iok In Christine Chio,
- Dan Hasson,
- Emily Bernstein,
- Ramon E. Parsons
Affiliations
- Royce W. Zhou
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Jia Xu
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Tiphaine C. Martin
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Alexis L. Zachem
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- John He
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Sait Ozturk
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Deniz Demircioglu
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Ankita Bansal
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Andrew P. Trotta
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Bruno Giotti
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Berkley Gryder
- Department of Genetics and Genome Sciences, Case Western Reserve University
- Yao Shen
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Xuewei Wu
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Saul Carcamo
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Kaitlyn Bosch
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Benjamin Hopkins
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Alexander Tsankov
- Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
- Randolph Steinhagen
- Division of Colon and Rectal Surgery, Department of Surgery, Icahn School of Medicine at Mount Sinai
- Drew R. Jones
- Metabolomics Core Resource Laboratory, NYU Langone Health
- John Asara
- Mass Spectrometry Core, Beth Israel Deaconess Medical Center
- Jerry E. Chipuk
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Rachel Brody
- Mount Sinai Biorepository, Department of Pathology, Icahn School of Medicine at Mount Sinai
- Steven Itzkowitz
- Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai
- Iok In Christine Chio
- Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Medical Center
- Dan Hasson
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Emily Bernstein
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Ramon E. Parsons
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s41467-022-33377-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
The changes in super-enhancer (SE) landscape of cancers are mainly attributed to cell-intrinsic genomic alterations. Here, the authors perform epigenomic profiling on primary colorectal cancers (CRCs) and their matched normal tissues and show that local tumour microenvironment induces a SE activation and that its target, PDZK1IP1 promotes CRC growth.
