Aortic aneurysm and non-Hodgkin’s lymphoma in Marfan syndrome

Abstract

The combination of Marfan syndrome with lymphoma is extremely rare. This report describes a case of Marfan syndrome who presented with chest discomfort and was diagnosed to have an aortic aneurysm and an additional incidental mediastinal mass that on further investigation turned out to be a diffuse large B cell lymphoma. We have suggested a hypothesis which can explain the occurrence of lymphoma in Marfan syndrome.

Keywords

• Marfan syndrome
• non-Hodgkin's Lymphoma
• aortic aneurysm
• TGF-beta
• Fibrillin