Communications Biology (Apr 2022)

Comprehensive genomics in androgen receptor-dependent castration-resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1

  • Yuki Makino,
  • Yuki Kamiyama,
  • J. B. Brown,
  • Toshiya Tanaka,
  • Ryusuke Murakami,
  • Yuki Teramoto,
  • Takayuki Goto,
  • Shusuke Akamatsu,
  • Naoki Terada,
  • Takahiro Inoue,
  • Tatsuhiko Kodama,
  • Osamu Ogawa,
  • Takashi Kobayashi

DOI
https://doi.org/10.1038/s42003-022-03227-w
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 14

Abstract

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Through comparative genomics using PDX models of androgen-dependent (AD) and androgen-resistant (AR) tumors, Makino et al. identify opioid receptor kappa 1 (OPRK1) as being associated with castration-resistance. Loss of OPRK1 function delays castration-resistance and inhibits castration-resistant growth of prostate cancer cells in culture and in vivo, suggesting OPRK1 as a therapeutic target.