228 Engineered human IL-2/IL-2Rß orthogonal pairs selectively enhance anti-GPC3 CAR T cells in vivo to drive complete responses in solid epithelial tumor models

• Martin Oft,
• Mohammed Ali,
• Ryan Burgess,
• Michele Bauer,
• Deepti Rokkam,
• Navneet Ratti,
• Sandro Vivona,
• Patrick Lupardus,
• Paul-Joseph Aspuria,
• Marie Semana,
• Ivan Cheng,
• Mahalaksmi Ramadass,
• Henry Rosas,
• George Zheng

Affiliations

Martin Oft

Synthekine, Menlo Park, CA, USA

Mohammed Ali

Department of Cardiology,Mercy University Hospital, Cork, Ireland

Ryan Burgess

1Synthekine, Menlo Park, CA, USA

Michele Bauer

1Synthekine, Menlo Park, CA, USA

Deepti Rokkam

1Synthekine, Menlo Park, CA, USA

Navneet Ratti

1Synthekine, Menlo Park, CA, USA

Sandro Vivona

1Synthekine, Menlo Park, CA, USA

Patrick Lupardus

1Synthekine, Menlo Park, CA, USA

Paul-Joseph Aspuria

Synthekine, Menlo Park, CA, USA

Marie Semana

Synthekine, Menlo Park, CA, USA

Ivan Cheng

Synthekine, Menlo Park, CA, USA

Mahalaksmi Ramadass

Synthekine, Menlo Park, CA, USA

Henry Rosas

Synthekine, Menlo Park, CA, USA

George Zheng

Synthekine, Menlo Park, CA, USA