The indices of thyroid system and metabolism of rats under the influence of nanocomposition based on iodine and citrate

Abstract

The search for a new biologically effective iodine compounds that may have practical use and do not cause toxic effects is relevant. The aim of the research was to examine the influence of nanocomposition based on citric acid – iodine helated compex (I2Citr) on the indices of thyroid system activity and metabolism in the blood serum of young male rats. Rats of the experimental groups received I2Citr with water daily for 40 days at a dose of 24 μg I/kg (1st experimental group) and 240 μg I/kg (2nd experimental group) of the body weight. The level of hormones and antibodies in the blood serum was determined with ELISA. Reduced Tg level and triacylglycerols content and elevated AntiTg, AntiTPO levels and Ca and albumin content in the serum of rats in both groups compared to control were observed. It was found that in the serum of rats in the 2nd experimental group the levels of T3, T4 and urea, as well as the activity of alkaline phosphatase and AlAT were reduced. No changes in the coefficients of the rats internal organs mass were detected under the action of I2Citr except for the spleen mass, which decreased by about 40% in the rats of 1st group and by 33% – in rats of 2nd group as compared to control. The data obtained indicate modulating influence of I2Citr in a studied doses on thyroid activity without causing toxic effects on animal organism.

Keywords

• internal organs mass of rats
• metabolic indices
• nanocomposition basede on iodine and citrate
• thyroid hormones