Медицинская иммунология (Jul 2014)

ASSOCIATIONS OF INTERFERON GENE POLYMORPHISMS OAS-1, OAS-3, PKR WITH CHRONIC VIRAL HEPATITIS C

  • V. A. Bychkov,
  • N. V. Ryazantseva,
  • V. V. Novitskiy,
  • N. A. Semenova,
  • L. A. Kleptsova,
  • V. D. Yakushina

DOI
https://doi.org/10.15789/1563-0625-2011-1-93-100
Journal volume & issue
Vol. 13, no. 1
pp. 93 – 100

Abstract

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Abstract. Present work is devoted to analyzing possible associations of single-nucleotide gene polymorphisms (SNPs) with liver pathology in patients with chronic hepatitis C. SNP genotypes and allele frequencies were identified for some genes of interferon system, i.e., oligoadenilatsynthetase-1 (-1A/G), oligoadenilatsynthetase-3 (+1314C/T), and protein kinase R (+244A/G), using DNA samples from healthy donors and patients with chronic hepatitis C representing population of Tomsk and Tomsk Region. An association has been shown between SNPs of oligoadenilatsynthetase-1 and protein kinase R genes, and clinical activity of inflammatory process in the liver, as well as an impact of certain SNPs of protein kinase R and oligoadenilatsynthetase-3 genes upon fibrogenesis. (Med. Immunol., 2011, vol. 13, N 1, pp 93-100)

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