Keratin-mediated hair growth and its underlying biological mechanism

Seong Yeong An; Hyo-Sung Kim; So Yeon Kim; Se Young Van; Han Jun Kim; Jae-Hyung Lee; Song Wook Han; Il Keun Kwon; Chul-Kyu Lee; Sun Hee Do; Yu-Shik Hwang

doi:10.1038/s42003-022-04232-9

Communications Biology (Nov 2022)

Keratin-mediated hair growth and its underlying biological mechanism

Seong Yeong An,
Hyo-Sung Kim,
So Yeon Kim,
Se Young Van,
Han Jun Kim,
Jae-Hyung Lee,
Song Wook Han,
Il Keun Kwon,
Chul-Kyu Lee,
Sun Hee Do,
Yu-Shik Hwang

Affiliations

Seong Yeong An: Department of Maxillofacial Biomedical Engineering, College of Dentistry, Kyung Hee University
Hyo-Sung Kim: Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University
So Yeon Kim: Department of Maxillofacial Biomedical Engineering, College of Dentistry, Kyung Hee University
Se Young Van: Department of Maxillofacial Biomedical Engineering, College of Dentistry, Kyung Hee University
Han Jun Kim: Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University
Jae-Hyung Lee: Department of Oral Microbiology, College of Dentistry, Kyung Hee University
Song Wook Han: KeraMedix Inc, # 204, Open Innovation Bld, Hongryeung Bio-Cluster
Il Keun Kwon: Department of Dental Materials, College of Dentistry, Kyung Hee University
Chul-Kyu Lee: Headquarters of New Drug Development Support
Sun Hee Do: Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University
Yu-Shik Hwang: Department of Maxillofacial Biomedical Engineering, College of Dentistry, Kyung Hee University

DOI: https://doi.org/10.1038/s42003-022-04232-9
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 17

Abstract

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Injecting human hair-derived keratin into mice skin accelerates hair growth & formation, as TGFβ2 secretion during hair destruction stimulates epithelial cell death and keratin release, leading to dermal cell condensation & hair growth.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal