Nature Communications (Aug 2019)
A phenotypic and genomics approach in a multi-ethnic cohort to subtype systemic lupus erythematosus
- Cristina M. Lanata,
- Ishan Paranjpe,
- Joanne Nititham,
- Kimberly E. Taylor,
- Milena Gianfrancesco,
- Manish Paranjpe,
- Shan Andrews,
- Sharon A. Chung,
- Brooke Rhead,
- Lisa F. Barcellos,
- Laura Trupin,
- Patricia Katz,
- Maria Dall’Era,
- Jinoos Yazdany,
- Marina Sirota,
- Lindsey A. Criswell
Affiliations
- Cristina M. Lanata
- Russell/Engleman Rheumatology Research Center, Department of Medicine, University of California San Francisco
- Ishan Paranjpe
- Bakar Computational Health Sciences Institute, University of California
- Joanne Nititham
- Russell/Engleman Rheumatology Research Center, Department of Medicine, University of California San Francisco
- Kimberly E. Taylor
- Russell/Engleman Rheumatology Research Center, Department of Medicine, University of California San Francisco
- Milena Gianfrancesco
- Russell/Engleman Rheumatology Research Center, Department of Medicine, University of California San Francisco
- Manish Paranjpe
- Bakar Computational Health Sciences Institute, University of California
- Shan Andrews
- Bakar Computational Health Sciences Institute, University of California
- Sharon A. Chung
- Russell/Engleman Rheumatology Research Center, Department of Medicine, University of California San Francisco
- Brooke Rhead
- University of California
- Lisa F. Barcellos
- University of California
- Laura Trupin
- Russell/Engleman Rheumatology Research Center, Department of Medicine, University of California San Francisco
- Patricia Katz
- Russell/Engleman Rheumatology Research Center, Department of Medicine, University of California San Francisco
- Maria Dall’Era
- Russell/Engleman Rheumatology Research Center, Department of Medicine, University of California San Francisco
- Jinoos Yazdany
- Russell/Engleman Rheumatology Research Center, Department of Medicine, University of California San Francisco
- Marina Sirota
- Bakar Computational Health Sciences Institute, University of California
- Lindsey A. Criswell
- Russell/Engleman Rheumatology Research Center, Department of Medicine, University of California San Francisco
- DOI
- https://doi.org/10.1038/s41467-019-11845-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease of substantial phenotypic heterogeneity in different ethnic groups. Here, using data from a multi-ethnic cohort, the authors describe an approach based on clinical and molecular data to subtype SLE patients into three clusters of severity.
