PLoS ONE (Jan 2011)

RosettaRemodel: a generalized framework for flexible backbone protein design.

  • Po-Ssu Huang,
  • Yih-En Andrew Ban,
  • Florian Richter,
  • Ingemar Andre,
  • Robert Vernon,
  • William R Schief,
  • David Baker

DOI
https://doi.org/10.1371/journal.pone.0024109
Journal volume & issue
Vol. 6, no. 8
p. e24109

Abstract

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We describe RosettaRemodel, a generalized framework for flexible protein design that provides a versatile and convenient interface to the Rosetta modeling suite. RosettaRemodel employs a unified interface, called a blueprint, which allows detailed control over many aspects of flexible backbone protein design calculations. RosettaRemodel allows the construction and elaboration of customized protocols for a wide range of design problems ranging from loop insertion and deletion, disulfide engineering, domain assembly, loop remodeling, motif grafting, symmetrical units, to de novo structure modeling.