Characteristics of cerebrospinal fluid oligoclonal band in anti-myelin oligodendrocyte glycoprotein (MOG) antibody associated disease
Wenjun Shao,
Xiaoni Liu,
Jiatong Li,
Tianyang Sheng,
Yarong Li,
Yuehua Gu,
Bo Deng,
Jingguo Wang,
Wenbo Yang,
Hai Yu,
Xiang Zhang,
Xiangjun Chen
Affiliations
Wenjun Shao
Department of Neurology, Huashan Hospital and Institute of Neurology, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China; Department of Neurology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, China
Xiaoni Liu
Department of Neurology, Huashan Hospital and Institute of Neurology, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China; National Center for Neurological Disorders, China
Jiatong Li
Department of Neurology, Huashan Hospital and Institute of Neurology, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China; National Center for Neurological Disorders, China
Tianyang Sheng
Department of Neurology, Huashan Hospital and Institute of Neurology, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China; National Center for Neurological Disorders, China
Yarong Li
Department of Neurology, Huashan Hospital and Institute of Neurology, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China; National Center for Neurological Disorders, China
Yuehua Gu
Department of Neurology, Huashan Hospital and Institute of Neurology, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China; National Center for Neurological Disorders, China
Bo Deng
Department of Neurology, Huashan Hospital and Institute of Neurology, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China; National Center for Neurological Disorders, China
Jingguo Wang
Department of Neurology, Huashan Hospital and Institute of Neurology, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China; National Center for Neurological Disorders, China
Wenbo Yang
Department of Neurology, Huashan Hospital and Institute of Neurology, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China; National Center for Neurological Disorders, China
Hai Yu
Department of Neurology, Huashan Hospital and Institute of Neurology, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China; National Center for Neurological Disorders, China
Xiang Zhang
Department of Neurology, Huashan Hospital and Institute of Neurology, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China; National Center for Neurological Disorders, China
Xiangjun Chen
Department of Neurology, Huashan Hospital and Institute of Neurology, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China; National Center for Neurological Disorders, China; Human Phenome Institute, Fudan University, Shanghai, China; Corresponding author. Department of Neurology, Huashan Hospital, Fudan University and National Center for Neurological Disorders, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
Objective: To analyze the immune parameters of cerebrospinal fluid (CSF) and oligoclonal band (OCB) type in patients with anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated diseases (MOGAD). Methods: Patients who were seropositive for MOG-IgG and diagnosed with MOGAD according to the diagnosis criteria in the Department of Neurology, Huashan Hospital, Fudan University from December 2020 to June 2022 were retrospectively included in this study. Complete clinical data, blood and cerebrospinal fluid samples were collected from all the participants. Paired serum and CSF MOG-IgG and autoimmune encephalitis antibody were assayed by Cell Based Assay (CBA) based on transfected target antigens. Paired serum and CSF albumin and IgG were detected by turbidimetric scattering method, and OCB was detected by standard operation procedure as described. Results: A total of 86 patients (44 males and 42 females) with MOGAD were included in this study, with a median age of 30 years (range: 5–82 years). Among all the patients, 73 patients showed OCB type I, 12 patients showed OCB type II, and one patient showed OCB type III. The overall positive rate of CSF-OCB in MOGAD patients was 15.1 %. The 24-h intrathecal synthesis rate of CSF in the OCB-positive group (n = 13) was higher than that in the OCB-negative group [n = 73, 0.62 (0.26) vs 5.11 (13.67), P = 0.003]. Subgroup analysis revealed that the positive rates of CSF-OCB in the single MOG group (n = 61) and the group combined with other antibodies (n = 25) were 14.8 % and 16.0 %, respectively. The incidence of meningoencephalitis (13/61 vs 13/25, P = 0.011) was significantly different between the two groups. The proportion of patients with high (≥1:32) or low (≤1:10) CSF MOG-IgG also showed significant difference in the group combined with other antibodies (P = 0.032). Optic neuritis was more common in the relapse course group (n = 49) than the monophasic course group (n = 37, P < 0.001) No significant diferences of CSF immune parameters were found in the MOG-IgGserum+/CSF− group and the MOG-IgGserum+/CSF + group, and the titer of MOG-IgG in the serum or CSF did not influence CSF immune parameters in different subgroups. Conclusion: The overall positive rate of CSF-OCB in MOGAD patients was 15.1 %. The 24-h intrathecal synthesis rate of cerebrospinal fluid in the OCB-positive group was higher than that in the OCB-negative group. This study illustrated OCB characterization in MOGAD patients, and will shed light on the standardization of OCB test in the study of immune diseases.
