Diabetes, Metabolic Syndrome and Obesity (Mar 2022)
Relationship Between Thyroid Hormone and Liver Steatosis Analysis Parameter in Obese Participants: A Case-Control Study
Abstract
Shuqin Chen,1,* Yong Jin,2,* Miao Xu,1 Pingping Zhang,3 Ye Zhou,1 Xingjun Qian,4 Qifa Song,5 Shizhong Bu,6 Jing Sun,7 Li Li1 1Department of Endocrinology and Metabolism, Ningbo First Hospital, Ningbo, Zhejiang Province, People’s Republic of China; 2Department of Internal Medicine, Ningbo Yinzhou Second Hospital, Ningbo, Zhejiang Province, People’s Republic of China; 3School of Public Health, Peking University, Beijing, People’s Republic of China; 4Health Management Center, Ningbo First Hospital, Ningbo, Zhejiang Province, People’s Republic of China; 5Medical Research Center, Ningbo First Hospital, Ningbo, Zhejiang Province, People’s Republic of China; 6Diabetes Research Center, School of Medicine, Ningbo University, Ningbo, Zhejiang Province, People’s Republic of China; 7School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland, Australia*These authors contributed equally to this workCorrespondence: Li Li, Department of Endocrinology and Metabolism, Ningbo First Hospital, Ningbo, Zhejiang Province, People’s Republic of China, Tel +8613757426626, Email [email protected] Jing Sun, School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland, Australia, Tel +61756780924, Email [email protected]: The thyroid hormone has been demonstrated to be associated with nonalcoholic fatty liver disease (NAFLD) in different populations. However, the relationship between thyroid hormone and the degree of liver steatosis in overweight/obese subjects is still unclear. Liver ultra-sound attenuation (LiSA) is a newly developed ultrasound attenuation parameter for the analysis of hepatic steatosis. The study aimed to characterize the relationship between thyroid hormone and LiSA in overweight/obese participants.Methods: This case-control study was performed in Ningbo First Hospital, China. A total of 24 lean, 66 overweight and 49 obese participants were consecutively recruited from January 2021 to May 2021. Thyroid hormone and other clinical features were measured. LiSA was acquired by using a Hepatus ultrasound machine. Multiple linear regression analyses were performed to examine associations of LiSA and clinic indices.Results: Obese subjects had higher LiSA, fT3 and TSH levels than lean participants of similar age and sex (P < 0.05). LiSA was positively associated with the fT3 level. The multiple linear regression analyses showed that fT3 (ß = 0.353, P < 0.001) was independently associated with LiSA in overweight/obese participants.Conclusion: The fT3 level was independently associated with the degree of liver steatosis among the overweight/obese participants.Keywords: LiSA, obesity, NAFLD, thyroid hormone
