SDF1α-induced chemotaxis of JAK2-V617F-positive cells is dependent on Bruton tyrosine kinase and its downstream targets PI3K/AKT, PLCγ1 and RhoA

• Subbaiah Chary Nimmagadda,
• Stephanie Frey,
• Peter Müller,
• Denise Wolleschak,
• Sönke Weinert,
• Ulrich Keller,
• Bärbel Edelmann,
• Thomas Fischer

Affiliations

Subbaiah Chary Nimmagadda

Department of Hematology and Oncology, Medical Center, Otto-von-Guericke University, Magdeburg;Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-University, Magdeburg;Medical Clinic and Polyclinic III, Klinikum rechts der Isar, Technical University Munich

Stephanie Frey

Department of Hematology and Oncology, Medical Center, Otto-von-Guericke University, Magdeburg;Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-University, Magdeburg

Peter Müller

Department of Hematology and Oncology, Medical Center, Otto-von-Guericke University, Magdeburg;Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-University, Magdeburg

Denise Wolleschak

Department of Hematology and Oncology, Medical Center, Otto-von-Guericke University, Magdeburg;Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-University, Magdeburg

Sönke Weinert

Department of Cardiology and Angiology, Medical Center, Otto-von-Guericke University, Magdeburg

Ulrich Keller

Medical Clinic and Polyclinic III, Klinikum rechts der Isar, Technical University Munich;Department of Hematology, Oncology and Tumor Immunology, Campus Benjamin Franklin, Charité -Universitätsmedizin, Berlin;German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany

Bärbel Edelmann

Department of Hematology and Oncology, Medical Center, Otto-von-Guericke University, Magdeburg;Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-University, Magdeburg

Thomas Fischer

Department of Hematology and Oncology, Medical Center, Otto-von-Guericke University, Magdeburg;Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-University, Magdeburg