Phylogeny-guided genome mining of roseocin family lantibiotics to generate improved variants of roseocin

Sandeep Chaudhary; Shweta Kishen; Mangal Singh; Sunanda Jassal; Reeva Pathania; Kalpana Bisht; Dipti Sareen

doi:10.1186/s13568-023-01536-9

AMB Express (Mar 2023)

Phylogeny-guided genome mining of roseocin family lantibiotics to generate improved variants of roseocin

Sandeep Chaudhary,
Shweta Kishen,
Mangal Singh,
Sunanda Jassal,
Reeva Pathania,
Kalpana Bisht,
Dipti Sareen

Affiliations

Sandeep Chaudhary: Department of Biochemistry, Panjab University
Shweta Kishen: Department of Biochemistry, Panjab University
Mangal Singh: Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee
Sunanda Jassal: Department of Biochemistry, Panjab University
Reeva Pathania: Department of Biochemistry, Panjab University
Kalpana Bisht: Department of Biochemistry, Panjab University
Dipti Sareen: Department of Biochemistry, Panjab University

DOI: https://doi.org/10.1186/s13568-023-01536-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 20

Abstract

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Keypoints Taxonomically distant species have a wide diversity of roseocin family lantibiotics. The phylogeny-guided approach opens new possibilities for RiPPs bioengineering. Bioactive variants of roseocin were generated using semi-in vitro reconstitution.

Published in AMB Express

ISSN: 2191-0855 (Online)
Publisher: SpringerOpen
Country of publisher: United Kingdom
LCC subjects: Technology: Chemical technology: Biotechnology; Science: Microbiology
Website: http://www.amb-express.com/

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Abstract

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