Phylogeny-guided genome mining of roseocin family lantibiotics to generate improved variants of roseocin

Abstract

Keypoints Taxonomically distant species have a wide diversity of roseocin family lantibiotics. The phylogeny-guided approach opens new possibilities for RiPPs bioengineering. Bioactive variants of roseocin were generated using semi-in vitro reconstitution.

Keywords

• Actinobacteria
• Lantibiotics
• Phylum
• Post-translational modification
• Variants