Nature Communications (Feb 2022)

IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defence

  • Hung-Yu Chiang,
  • Hsueh-Han Lu,
  • Janaki N. Sudhakar,
  • Yu-Wen Chen,
  • Nien-Shin Shih,
  • Yi-Ting Weng,
  • Jr-Wen Shui

DOI
https://doi.org/10.1038/s41467-022-28478-3
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 19

Abstract

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IL-22 induces IL-18 expression by intestinal epithelial cells. Authors show here that IL-18 is a key barrier maintenance factor during adherent-invasive E. coli invasion, inducing expression of anti-microbial genes in Paneth cells via Stat3, prompting IFNγ expression in T cells and triggering intestinal Lgr5+ stem cell expansion via Tcf4.