Nature Communications (Dec 2020)

XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis

  • Huan Meng,
  • Naomi M. Gonzales,
  • David M. Lonard,
  • Nagireddy Putluri,
  • Bokai Zhu,
  • Clifford C. Dacso,
  • Brian York,
  • Bert W. O’Malley

DOI
https://doi.org/10.1038/s41467-020-20028-z
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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Hepatocyte 12-hour rhythms have a role in cellular stress and metabolic functions. Here, the authors demonstrate disrupting the 12-hour clock through deletion of XBP1 is associated with the development of NAFLD as well as disruption of phospholipid composition and the maintenance of lipid homeostasis.