Analysis of the Evolution of Pandemic Influenza A(H1N1) Virus Neuraminidase Reveals Entanglement of Different Phenotypic Characteristics
Meiling Dai,
Wenjuan Du,
Carles Martínez-Romero,
Tim Leenders,
Tom Wennekes,
Guus F. Rimmelzwaan,
Frank J. M. van Kuppeveld,
Ron A. M. Fouchier,
Adolfo Garcia-Sastre,
Erik de Vries,
Cornelis A. M. de Haan
Affiliations
Meiling Dai
Virology Section, Division of Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
Wenjuan Du
Virology Section, Division of Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
Carles Martínez-Romero
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Tim Leenders
Department Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands
Tom Wennekes
Department Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands
Guus F. Rimmelzwaan
Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine, Hannover, Germany
Frank J. M. van Kuppeveld
Virology Section, Division of Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
Ron A. M. Fouchier
Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Erik de Vries
Virology Section, Division of Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
Virology Section, Division of Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
Since its emergence in 2009, the pandemic H1N1 influenza A virus (IAV) has caused significant disease and mortality in humans. IAVs contain two envelope glycoproteins, the receptor-binding hemagglutinin (HA) and the receptor-destroying neuraminidase (NA).
