Analysis of the Evolution of Pandemic Influenza A(H1N1) Virus Neuraminidase Reveals Entanglement of Different Phenotypic Characteristics

Meiling Dai; Wenjuan Du; Carles Martínez-Romero; Tim Leenders; Tom Wennekes; Guus F. Rimmelzwaan; Frank J. M. van Kuppeveld; Ron A. M. Fouchier; Adolfo Garcia-Sastre; Erik de Vries; Cornelis A. M. de Haan

doi:10.1128/mBio.00287-21

mBio (Jun 2021)

Analysis of the Evolution of Pandemic Influenza A(H1N1) Virus Neuraminidase Reveals Entanglement of Different Phenotypic Characteristics

Meiling Dai,
Wenjuan Du,
Carles Martínez-Romero,
Tim Leenders,
Tom Wennekes,
Guus F. Rimmelzwaan,
Frank J. M. van Kuppeveld,
Ron A. M. Fouchier,
Adolfo Garcia-Sastre,
Erik de Vries,
Cornelis A. M. de Haan

Affiliations

Meiling Dai: Virology Section, Division of Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
Wenjuan Du: Virology Section, Division of Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
Carles Martínez-Romero: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Tim Leenders: Department Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands
Tom Wennekes: Department Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands
Guus F. Rimmelzwaan: Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine, Hannover, Germany
Frank J. M. van Kuppeveld: Virology Section, Division of Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
Ron A. M. Fouchier: Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands
Adolfo Garcia-Sastre: ORCiD; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Erik de Vries: Virology Section, Division of Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
Cornelis A. M. de Haan: ORCiD; Virology Section, Division of Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands

DOI: https://doi.org/10.1128/mBio.00287-21
Journal volume & issue: Vol. 12, no. 3

Abstract

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Since its emergence in 2009, the pandemic H1N1 influenza A virus (IAV) has caused significant disease and mortality in humans. IAVs contain two envelope glycoproteins, the receptor-binding hemagglutinin (HA) and the receptor-destroying neuraminidase (NA).

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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