Nature Communications (Apr 2019)
Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance
- Shun Li,
- Ying Song,
- Christine Quach,
- Hongrui Guo,
- Gyu-Beom Jang,
- Hadi Maazi,
- Shihui Zhao,
- Nathaniel A. Sands,
- Qingsong Liu,
- Gino K. In,
- David Peng,
- Weiming Yuan,
- Keigo Machida,
- Min Yu,
- Omid Akbari,
- Ashley Hagiya,
- Yongfei Yang,
- Vasu Punj,
- Liling Tang,
- Chengyu Liang
Affiliations
- Shun Li
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Ying Song
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Christine Quach
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Hongrui Guo
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Gyu-Beom Jang
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Hadi Maazi
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Shihui Zhao
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Nathaniel A. Sands
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Qingsong Liu
- High Magnetic Field Laboratory, Chinese Academy of Sciences
- Gino K. In
- Norris Comprehensive Cancer, Division of Oncology, University of Southern California
- David Peng
- Department of Dermatology, Keck School of Medicine, University of Southern California
- Weiming Yuan
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Keigo Machida
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Min Yu
- Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California
- Omid Akbari
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Ashley Hagiya
- Department of Pathology, Keck School of Medicine, University of Southern California
- Yongfei Yang
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Vasu Punj
- Department of Pathology, Keck School of Medicine, University of Southern California
- Liling Tang
- Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University
- Chengyu Liang
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- DOI
- https://doi.org/10.1038/s41467-019-09634-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 18
Abstract
The relationship between autophagy and BRAF signalling is unclear. Here, the authors describe that BRAF inhibition induces the autophagy-lysosomal function in BRAF-mutant melanomas via modulation of the TFEB and ZKSCAN3 transcriptome, which downregulates TGF-β and suppresses melanoma progression.
