Absorbed Dose of Human Organs after Injection of 68Ga-EDTMP: Estimation from Biodistribution Data in Wild-Type Rats

Abstract

Purpose: 68Ga is a generator-based radionuclide with suitable characteristics for PET imaging. 68Ga-EDTMP has recently been introduced as a new agent for bone imaging. In this study, the human absorbed dose of this agent was calculated according to RADAR method and based on the bio-distribution data in Wild-type rats. Materials and Methods: 68Ga was obtained from 68Ge/68Ga generator. While, the radiolabeled complex was prepared in the optimized conditions, the radiochemical purity was checked by Instant Thin Layer Chromatography (ITLC) method. Absorbed dose of each human organ was calculated following the bio-distribution assessment of the complex in the Wild-type rats up to 120 min. Results: 68Ga was prepared with radionuclidic purity and radiochemical purity of higher than 99%. The results indicated the radiochemical purity of higher than 99% for 68Ga-EDTMP. As expected, bone surface and bone marrow with 0.112 and 0.053 mSv/MBq, respectively, received the highest absorbed dose. The dose of total body was estimated to be 0.006 mSv/MBq. Conclusion: according to the results, the radiolabeled complex can be considered as a safe agent for bone imaging.

Keywords

• Absorbed Dose
• Bone Imaging
• Ethylenediamine Tetra Methylene Phosphonic Acid
• 68Ga
• RAdio Detection and Ranging