Microfluidic Organ-on-a-Chip Models of Human IntestineSummary

Amir Bein; Woojung Shin; Sasan Jalili-Firoozinezhad; Min Hee Park; Alexandra Sontheimer-Phelps; Alessio Tovaglieri; Angeliki Chalkiadaki; Hyun Jung Kim; Donald E. Ingber

Cellular and Molecular Gastroenterology and Hepatology (Jan 2018)

Microfluidic Organ-on-a-Chip Models of Human IntestineSummary

Amir Bein,
Woojung Shin,
Sasan Jalili-Firoozinezhad,
Min Hee Park,
Alexandra Sontheimer-Phelps,
Alessio Tovaglieri,
Angeliki Chalkiadaki,
Hyun Jung Kim,
Donald E. Ingber

Affiliations

Amir Bein: Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts
Woojung Shin: Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas
Sasan Jalili-Firoozinezhad: Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts; Department of Bioengineering and iBB - Institute for Bioengineering and Biosciences, Instituto Superior Técnico, University of Lisbon, Lisbon, Portugal
Min Hee Park: Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas
Alexandra Sontheimer-Phelps: Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts; Graduate Program, Faculty of Biology, University of Freiburg, Freiburg, Germany
Alessio Tovaglieri: Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts; Graduate Program, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland
Angeliki Chalkiadaki: Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts
Hyun Jung Kim: Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas; Hyun Jung Kim, PhD, Department of Biomedical Engineering, The University of Texas at Austin, 107 West Dean Keeton Street, BME 4.202C, Austin, Texas 78712.
Donald E. Ingber: Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts; Vascular Biology Program and Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts; Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, Massachusetts; Correspondence Address correspondence to: Donald E. Ingber, MD, PhD, Wyss Institute at Harvard University, CLSB Building, 5th floor, 3 Blackfan Circle, Boston, Massachusetts 02115. fax: 617-432-7048

Journal volume & issue: Vol. 5, no. 4
pp. 659 – 668

Abstract

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Microfluidic organ-on-a-chip models of human intestine have been developed and used to study intestinal physiology and pathophysiology. In this article, we review this field and describe how microfluidic Intestine Chips offer new capabilities not possible with conventional culture systems or organoid cultures, including the ability to analyze contributions of individual cellular, chemical, and physical control parameters one-at-a-time; to coculture human intestinal cells with commensal microbiome for extended times; and to create human-relevant disease models. We also discuss potential future applications of human Intestine Chips, including how they might be used for drug development and personalized medicine. Keywords: Organs-on-Chips, Gut-on-a-Chip, Intestine-on-a-Chip, Microfluidic

Published in Cellular and Molecular Gastroenterology and Hepatology

ISSN: 2352-345X (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
Website: https://www.journals.elsevier.com/cellular-and-molecular-gastroenterology-and-hepatology/

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