Nature Communications (Oct 2022)

Consequences of telomere dysfunction in fibroblasts, club and basal cells for lung fibrosis development

  • Sergio Piñeiro-Hermida,
  • Paula Martínez,
  • Giuseppe Bosso,
  • Juana María Flores,
  • Sarita Saraswati,
  • Jane Connor,
  • Raphael Lemaire,
  • Maria A. Blasco

DOI
https://doi.org/10.1038/s41467-022-32771-6
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 18

Abstract

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Telomere dysfunction induced by TRF1 depletion in fibroblasts, club and basal cells did not lead to interstitial lung fibrosis, underscoring alveolar type II cells as the relevant cell type in pulmonary fibrosis.