Hepatic Transcriptome Profiles of Mice with  Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E

Masuko Kobori; Yumiko Takahashi; Mutsumi Sakurai; Yinhua Ni; Guanliang Chen; Mayumi Nagashimada; Shuichi Kaneko; Tsuguhito Ota

doi:10.3390/ijms18030593

International Journal of Molecular Sciences (Mar 2017)

Hepatic Transcriptome Profiles of Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E

Masuko Kobori,
Yumiko Takahashi,
Mutsumi Sakurai,
Yinhua Ni,
Guanliang Chen,
Mayumi Nagashimada,
Shuichi Kaneko,
Tsuguhito Ota

Affiliations

Masuko Kobori: Food Research Institute, National Agriculture and Food Resrach Organization, Tsukuba, Ibaraki 305-8642, Japan
Yumiko Takahashi: Food Research Institute, National Agriculture and Food Resrach Organization, Tsukuba, Ibaraki 305-8642, Japan
Mutsumi Sakurai: Food Research Institute, National Agriculture and Food Resrach Organization, Tsukuba, Ibaraki 305-8642, Japan
Yinhua Ni: Department of Cell Metabolism and Nutrition, Brain/Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan
Guanliang Chen: Department of Cell Metabolism and Nutrition, Brain/Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan
Mayumi Nagashimada: Department of Cell Metabolism and Nutrition, Brain/Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan
Shuichi Kaneko: Department of Cell Metabolism and Nutrition, Brain/Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan
Tsuguhito Ota: Department of Cell Metabolism and Nutrition, Brain/Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan

DOI: https://doi.org/10.3390/ijms18030593
Journal volume & issue: Vol. 18, no. 3
p. 593

Abstract

Read online

Astaxanthin alleviates hepatic lipid accumulation and peroxidation, inflammation, and fibrosis in mice with high-cholesterol, high-cholate, and high-fat (CL) diet-induced nonalcoholic steatohepatitis (NASH) [...]

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

About the journal

Abstract

Keywords