Diabetes, Metabolic Syndrome and Obesity (Jan 2024)
The Correlation Between Glycation Gap and Renal Complications in Patients with Type 2 Diabetes Mellitus
Abstract
Tuan Quoc Le,1 Khanh Minh Thanh,1 Tien Van Tran,2 Dao Thi Bich Nguyen,3 Le Thi Nguyen,4 Diep Thao Pham,5 Lan Thi Phuong Dam,6 Minh Thị Hoang,6 Thuan Quang Huynh6 1Department of Physiology-Pathophysiology-Immunology, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam; 2Department of Nephrology, Ho Chi Minh City Hospital for Rehabilitation - Professional Diseases, Ho Chi Minh City, Vietnam; 3Tam Duc Heart Hospital, Ho Chi Minh City, Vietnam; 4Nephrology Department, University Medical Center, Ho Chi Minh City, Vietnam; 5Biochemistry Department, Viet Duc Hospital, Ha Noi, Vietnam; 6Biochemistry Department, 103 Military Medical Hospital, Vietnam Military Medical University (VMMU), Ha Noi City, VietnamCorrespondence: Thuan Quang Huynh, Biochemistry Department, 103 Military Medical Hospital, Vietnam Military Medical University (VMMU), No. 160, Phung Hung Street, Phuc La Ward, Ha Dong District, Hanoi City, Vietnam, Tel +84904175342, Email [email protected]: The aim of this study was to investigate the correlations between the glycation gap (GG) and renal complications such as urinary albumin–creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) in type 2 diabetes mellitus patients.Materials and Methods: A cross-sectional study was conducted on 104 individuals (52 males and 52 females), aged 36– 93 years old. Fasting blood glucose (FBG), HbA1c, and serum fructosamine were measured simultaneously. GG was calculated as the difference between the measured and fructosamine-based predicted HbA1c levels (FHbA1c).Results: There was a moderately positive correlation between HbA1c and fructosamine concentration (r = 0.488; p < 0.001). GG was positively correlated with UACR (r = 0.3275; p = 0.0007), negatively correlated with eGFR (r = − 0.3400; p = 0.0004). HbA1c was positively correlated with UACR (r = 0.2437; p = 0.0127) but not correlated with eGFR (r = − 0.444; p = 0.6542). Fructosamine has a positive correlation with eGFR (r = 0.2426; p = 0.0131) but not with UACR (r = − 0.1021; p = 0.3025).Conclusion: GG was positively correlated with UACR and inversely correlated with eGFR in type 2 Diabetes mellitus patients. This suggests that GG is a valuable index for predicting kidney complications due to diabetes.Keywords: type 2 diabetes, HbA1c, fructosamine, glycated gap, glomerular filtration rate, urinary albumin-creatinine ratio
