Drug Design, Development and Therapy (Nov 2020)
Interaction of Analgesic Effects of Dezocine and Sufentanil for Relief of Postoperative Pain: A Pilot Study
Abstract
He Zhu,1,* Yaobing Chen,2,* Shaoqiang Huang,2 Xingfeng Sun2 1Department of Anesthesiology, Tianjin Central Hospital of Gynecology and Obstetrics, Tianjin 300199, People’s Republic of China; 2Department of Anesthesiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200093, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shaoqiang Huang; Xingfeng SunDepartment of Anesthesiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200093, People’s Republic of ChinaTel +86-021-33189900-6868Fax +86-021-63453522Email [email protected]; [email protected]: The combination of dezocine and sufentanil is often used for postoperative analgesia in China and other areas, but the interaction of both two drugs is still unclear. The purpose of this study was to evaluate the interaction of the analgesic effects of dezocine and sufentanil in the patients after gynecological laparoscopic surgery.Patients and Methods: We conducted a prospective, randomized, double-blinded clinical trial. A total of 150 patients were divided into 5 groups (30 in each group) in the post-anesthesia care unit, namely, dezocine group (Group D), sufentanil group (Group S) and dezocine mixed sufentanil groups (Group DS1-3). In group D and S, the initial dose of dezocine or sufentanil was 5mg and 5μg intravenously, respectively. In Group DS1, the initial dose was dezocine 5mg × 3/4 and sufentanil 5μg × 1/4. In Group DS2, the initial dose was dezocine 5mg × 1/2 and sufentanil 5μg × 1/2. In Group DS3, the initial dose was dezocine 5mg × 1/4 and sufentanil 5μg × 3/4.Results: The median effective dose (ED50) of dezocine and sufentanil alone was 3.92 (95% confidence interval (CI) 3.01∼ 4.64) mg and 3.71 (95% CI 2.78∼ 4.39) μg, respectively. The isobolographic analysis showed that the combination of dezocine and sufentanil at 1:3, 1:1 or 3:1 appeared in the additive line.Conclusion: In conclusion, when simultaneously administered intravenously, combined dezocine and sufentanil produce an additive effect for relieving the acute nociception after gynecological laparoscopic surgery.Keywords: dezocine, sufentanil, analgesia, intravenous, laparoscopy
