Nature Communications (Feb 2021)
Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival
- Jiwei Bai,
- Jianxin Shi,
- Chuzhong Li,
- Shuai Wang,
- Tongwu Zhang,
- Xing Hua,
- Bin Zhu,
- Hela Koka,
- Ho-Hsiang Wu,
- Lei Song,
- Difei Wang,
- Mingyi Wang,
- Weiyin Zhou,
- Bari J. Ballew,
- Bin Zhu,
- Belynda Hicks,
- Lisa Mirabello,
- Dilys M. Parry,
- Yixuan Zhai,
- Mingxuan Li,
- Jiang Du,
- Junmei Wang,
- Shuheng Zhang,
- Qian Liu,
- Peng Zhao,
- Songbai Gui,
- Alisa M. Goldstein,
- Yazhuo Zhang,
- Xiaohong R. Yang
Affiliations
- Jiwei Bai
- Beijing Neurosurgical Institute, Capital Medical University
- Jianxin Shi
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Chuzhong Li
- Beijing Neurosurgical Institute, Capital Medical University
- Shuai Wang
- Beijing Neurosurgical Institute, Capital Medical University
- Tongwu Zhang
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Xing Hua
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Bin Zhu
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Hela Koka
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Ho-Hsiang Wu
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Lei Song
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Difei Wang
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Mingyi Wang
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Weiyin Zhou
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Bari J. Ballew
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Bin Zhu
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Belynda Hicks
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Lisa Mirabello
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Dilys M. Parry
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Yixuan Zhai
- Beijing Neurosurgical Institute, Capital Medical University
- Mingxuan Li
- Beijing Neurosurgical Institute, Capital Medical University
- Jiang Du
- Beijing Neurosurgical Institute, Capital Medical University
- Junmei Wang
- Beijing Neurosurgical Institute, Capital Medical University
- Shuheng Zhang
- Beijing Neurosurgical Institute, Capital Medical University
- Qian Liu
- Beijing Neurosurgical Institute, Capital Medical University
- Peng Zhao
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University
- Songbai Gui
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University
- Alisa M. Goldstein
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- Yazhuo Zhang
- Beijing Neurosurgical Institute, Capital Medical University
- Xiaohong R. Yang
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
- DOI
- https://doi.org/10.1038/s41467-021-21026-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Skull base chordomas are treated with surgery and chemotherapy but often recur due to incomplete resection, understanding the molecular underpinnings of the tumours may provide additional therapeutic strategies. Here, the authors carry out whole genome sequencing of 80 skull base chordoma tumours and identify the SWI/SNF component—PBRM1—as a frequently mutated gene.
