EFFECTS OF POLYMORPHISM rs3846663 IN HMG-COA REDUCTAASE GENE ON TOTAL CHOLESTEROL METABOLISM IN WOMAN

Abstract

The purpose of this study was to establish an association between polymorphism rs3846663 in the HMG-CoA reductase gene and total cholesterol in relatively healthy individuals, without gender specification, as well as in men and in women separately. The study was conducted in a group of 173 relatively healthy individuals (105 women, 68 men). In order to identify single nucleotide polymorphism, minisequencing was applied with matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-ToF/MS) for subsequent detection of the reaction products. In this study, total cholesterol levels in carriers of pathological genotypes (CT and TT) of rs3846663 in the HMG-CoA reductase gene were significantly higher than in individuals with a normal CC genotype. It was also found that carrying CT and TT genotypes increases the risk of elevated total cholesterol as compared to the target levels. Total cholesterol in women carrying CT and TT genotypes of rs3846663 in the HMG-CoA reductase gene was statistically significantly higher. Moreover, the risk of elevated total cholesterol was also high. In healthy men, the presence of a pathological T allele did not affect the total cholesterol levels.

Keywords

• HMGСR
• ишемическая болезнь сердца
• гиперхолестеринемия
• rs3846663
• холестерин