Nature Communications (Dec 2018)

Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing

  • Michael Bartoschek,
  • Nikolay Oskolkov,
  • Matteo Bocci,
  • John Lövrot,
  • Christer Larsson,
  • Mikael Sommarin,
  • Chris D. Madsen,
  • David Lindgren,
  • Gyula Pekar,
  • Göran Karlsson,
  • Markus Ringnér,
  • Jonas Bergh,
  • Åsa Björklund,
  • Kristian Pietras

DOI
https://doi.org/10.1038/s41467-018-07582-3
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

Read online

Cancer-associated fibroblasts (CAFs) are an important component of the breast tumour microenvironment. Here, single-cell RNA sequencing of CAFs from a mouse model of breast cancer defines three transcriptomically distinct subpopulations with putatively different functions.