Nature Communications (Nov 2022)
Deciphering the heterogeneity of the Lyve1+ perivascular macrophages in the mouse brain
- C. Siret,
- M. van Lessen,
- J. Bavais,
- H. W. Jeong,
- S. K. Reddy Samawar,
- K. Kapupara,
- S. Wang,
- M. Simic,
- L. de Fabritus,
- A. Tchoghandjian,
- M. Fallet,
- H. Huang,
- S. Sarrazin,
- M. H. Sieweke,
- R. Stumm,
- L. Sorokin,
- R. H. Adams,
- S. Schulte-Merker,
- F. Kiefer,
- S. A. van de Pavert
Affiliations
- C. Siret
- Aix-Marseille Univ, CNRS, INSERM, Centre d’Immunologie de Marseille-Luminy (CIML)
- M. van Lessen
- Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, University of Münster
- J. Bavais
- Aix-Marseille Univ, CNRS, INSERM, Centre d’Immunologie de Marseille-Luminy (CIML)
- H. W. Jeong
- Max Planck Institute for Molecular Biomedicine
- S. K. Reddy Samawar
- Institute of Physiological Chemistry and Pathobiochemistry and Cells in Motion Interfaculty Centre (CIMIC), University of Münster
- K. Kapupara
- Institute of Physiological Chemistry and Pathobiochemistry and Cells in Motion Interfaculty Centre (CIMIC), University of Münster
- S. Wang
- Aix-Marseille Univ, CNRS, INSERM, Centre d’Immunologie de Marseille-Luminy (CIML)
- M. Simic
- Aix-Marseille Univ, CNRS, INSERM, Centre d’Immunologie de Marseille-Luminy (CIML)
- L. de Fabritus
- Aix-Marseille Univ, CNRS, INSERM, Centre d’Immunologie de Marseille-Luminy (CIML)
- A. Tchoghandjian
- Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol
- M. Fallet
- Aix-Marseille Univ, CNRS, INSERM, Centre d’Immunologie de Marseille-Luminy (CIML)
- H. Huang
- Aix-Marseille Univ, CNRS, INSERM, Centre d’Immunologie de Marseille-Luminy (CIML)
- S. Sarrazin
- Aix-Marseille Univ, CNRS, INSERM, Centre d’Immunologie de Marseille-Luminy (CIML)
- M. H. Sieweke
- Aix-Marseille Univ, CNRS, INSERM, Centre d’Immunologie de Marseille-Luminy (CIML)
- R. Stumm
- Institute of Pharmacology and Toxicology, Jena University Hospital
- L. Sorokin
- Institute of Physiological Chemistry and Pathobiochemistry and Cells in Motion Interfaculty Centre (CIMIC), University of Münster
- R. H. Adams
- Max Planck Institute for Molecular Biomedicine
- S. Schulte-Merker
- Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, University of Münster
- F. Kiefer
- Max Planck Institute for Molecular Biomedicine
- S. A. van de Pavert
- Aix-Marseille Univ, CNRS, INSERM, Centre d’Immunologie de Marseille-Luminy (CIML)
- DOI
- https://doi.org/10.1038/s41467-022-35166-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Perivascular macrophages (pvMs) are important for brain drainage and immune regulation. Here the authors analyse various reporter mouse strains for finer mapping of pvM subsets and lineage differentiation, and propose CX3CR1negative and CD45low as additional markers of intermediate pvMs for studying this heterogenous population.
