Nature Communications (May 2017)

Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis

  • Mei Zhou,
  • Hong Yang,
  • R. Marc Learned,
  • Hui Tian,
  • Lei Ling

DOI
https://doi.org/10.1038/ncomms15433
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 16

Abstract

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Fibroblast Growth Factor 19 (FGF19) neutralizing antibodies inhibit hepatocellular carcinoma (HCC) growth but have safety issues. Here, the authors show that FGF19 promotes HCC by activating STAT3 signalling via IL-6 production and that targeting IL-6 pathway abolishes FGF19-induced HCC without side effects.