Splicing is an alternate oncogenic pathway activation mechanism in glioma

Robert Siddaway; Scott Milos; Arun Kumaran Anguraj Vadivel; Tara H. W. Dobson; Jyothishmathi Swaminathan; Scott Ryall; Sanja Pajovic; Palak G. Patel; Javad Nazarian; Oren Becher; Michael Brudno; Arun Ramani; Vidya Gopalakrishnan; Cynthia Hawkins

doi:10.1038/s41467-022-28253-4

Nature Communications (Jan 2022)

Splicing is an alternate oncogenic pathway activation mechanism in glioma

Robert Siddaway,
Scott Milos,
Arun Kumaran Anguraj Vadivel,
Tara H. W. Dobson,
Jyothishmathi Swaminathan,
Scott Ryall,
Sanja Pajovic,
Palak G. Patel,
Javad Nazarian,
Oren Becher,
Michael Brudno,
Arun Ramani,
Vidya Gopalakrishnan,
Cynthia Hawkins

Affiliations

Robert Siddaway: Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
Scott Milos: Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
Arun Kumaran Anguraj Vadivel: Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
Tara H. W. Dobson: Department of Pediatrics - Research, The University of Texas MD Anderson Cancer Center
Jyothishmathi Swaminathan: Department of Pediatrics - Research, The University of Texas MD Anderson Cancer Center
Scott Ryall: Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
Sanja Pajovic: Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
Palak G. Patel: Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
Javad Nazarian: Department of Integrative Systems Biology, Children’s National Medical Center, George Washington University
Oren Becher: Ann & Robert H. Lurie Children’s Hospital of Chicago
Michael Brudno: Department of Computer Science, University of Toronto
Arun Ramani: Centre for Computational Medicine, The Hospital for Sick Children
Vidya Gopalakrishnan: Department of Pediatrics - Research, The University of Texas MD Anderson Cancer Center
Cynthia Hawkins: Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children

DOI: https://doi.org/10.1038/s41467-022-28253-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Targeting genetic drivers of high grade diffuse glioma (HGG) has not improved patient survival, suggesting the involvement of other mechanisms. Here, across cancer types, the authors identify increased alternative splicing burden in cancer drivers compared to mutation rate as an alternative mechanism for activation of oncogenic pathways such as RAS/MAPK.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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