Communications Biology (Mar 2022)
Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion
- Anna Veprik,
- Geoffrey Denwood,
- Dong Liu,
- Rula Bany Bakar,
- Valentin Morfin,
- Kara McHugh,
- Nchimunya N. Tebeka,
- Laurène Vetterli,
- Ekaterina Yonova-Doing,
- Fiona Gribble,
- Frank Reimann,
- Kyle L. Hoehn,
- Piers A. Hemsley,
- Jonas Ahnfelt-Rønne,
- Patrik Rorsman,
- Quan Zhang,
- Heidi de Wet,
- James Cantley
Affiliations
- Anna Veprik
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Geoffrey Denwood
- The Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford
- Dong Liu
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Rula Bany Bakar
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Valentin Morfin
- Division of Systems Medicine, School of Medicine, University of Dundee
- Kara McHugh
- School of Life Sciences, University of Dundee
- Nchimunya N. Tebeka
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Laurène Vetterli
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Ekaterina Yonova-Doing
- Novo Nordisk Research Centre Oxford
- Fiona Gribble
- Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Institute of Metabolic Science, Addenbrooke’s Hospital
- Frank Reimann
- Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Institute of Metabolic Science, Addenbrooke’s Hospital
- Kyle L. Hoehn
- School of Biotechnology and Biomolecular Sciences, University of New South Wales
- Piers A. Hemsley
- School of Life Sciences, University of Dundee
- Jonas Ahnfelt-Rønne
- Department of Pathology and Imaging, Novo Nordisk A/S
- Patrik Rorsman
- The Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford
- Quan Zhang
- The Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford
- Heidi de Wet
- Department of Physiology, Anatomy and Genetics, University of Oxford
- James Cantley
- Department of Physiology, Anatomy and Genetics, University of Oxford
- DOI
- https://doi.org/10.1038/s42003-022-03170-w
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 13
Abstract
Veprik et al. show that Acetyl-CoA-carboxylase 1 (ACC1), an enzyme that couples glucose metabolism to lipogenesis, is involved in glucagon secretion and regulates S-acylation of critical glucose-sensing proteins. Loss of ACC1 in pancreatic alpha-cells negatively affects both size and number, as well as glucagon content, while in gut enteroendocrine cells leads to reduced release of glucagon-like peptide 1.
