NOOTROPICS AND MELAXEN’ NEUROPROTECTIONAL ACTIVITY MORPHOPHARMACOLOGICAL ANALYSIS IN RATS’ ACUTE CEREBRAL ISCHEMIA

Abstract

purpose: оn the base of complex morpho-pharmacological analysis to evaluate nootropics and its combinations with melaxen effects in rats experimental acute cerebral ischemia.materials and methods: morphological (light-, electron microscopic and morphometric) analysis of the experimental material(frontal cortex and hippocampus) and lethality was studied on 21 white rats with induced by the ligation of bilateral common carotid arteries of acute cerebral ischemia and used a preventive course of nootropics (vinpocetine, piracetam) and melaxen.results: it was established that preventive combined vinpocetine and melaxen usage significantly reduces rat’s lethality and brain ischemic damage degree, indicating obvious neuroprotective activity.summary: the results obtained indicate significant potential importance of melatonin-based drugs usage for neuroprotection therapy emprovement in cerebral ischemia.

Keywords

• cerebral ischemia, neuroprotection, nootropics, melaxen, ultrastructure