Comparison of Clinical and Biochemical Parameters in Adolescent and Adult Patients with Polycyctic Ovary Syndrome

Abstract

Objective: We investigated whether there is a difference in clinical, biochemical, and hormonal parameters, BMI, Free androgen index between patients diagnosed with polycystic ovary syndrome (PCOS) in adolescence and in adulthood. Methods: Between May 2021 and October 2021, 75 adolescent patients with PCOS and 75 adult patients with PCOS diagnosed according to 2003 Rotterdam ASRM/ESHRE criteria were included in the study. Demographic and clinical characteristics of the patients, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), anti-Müllerian hormone (AMH), thyroid stimulating hormone (TSH), prolactin (PRL), and 17-hydroxyprogesterone (17-OHP), sex hormone initiating globulin, and dehydroxyepiandrostenedione sulfate and Fee androgen index levels were recorded. Results: Body mass index (BMI) was significantly lower in adolescent patients with PCOS compared with adult patients with PCOS (23.3+-2.9 kg/m2 vs 28.5+-4.8 kg/m2, p>0.001). FSH, LH, E2, progesterone, TSH, 17-OHP and total testosterone levels and LH/FSH ratio were similar between groups (p>0.05). Prolactin (19.77+-8.67 ng/mL vs 16.62+-7.80 ng/mL, p=0.02) and AMH (6.68+-4.40 ng/mL vs 5.34+-3.55 ng/mL, p=0.04) levels were significantly higher in the adolescent group than the adult group. Conclusion: AMH and prolactin levels were higher, and BMI was significantly lower in adolescent patients with PCOS compared with adult patients with PCOS. The etiopathogenesis of PCOS in adolescence and adulthood may be due to different mechanisms and hormonal changes. Large -scale prospective trials are needed to make a definitive statement on this subject.

Keywords

• polycystic ovary syndrome
• adolescent
• adult
• amh