Interaction of 7SK with the Smn complex modulates snRNP production

Changhe Ji; Jakob Bader; Pradhipa Ramanathan; Luisa Hennlein; Felix Meissner; Sibylle Jablonka; Matthias Mann; Utz Fischer; Michael Sendtner; Michael Briese

doi:10.1038/s41467-021-21529-1

Nature Communications (Feb 2021)

Interaction of 7SK with the Smn complex modulates snRNP production

Changhe Ji,
Jakob Bader,
Pradhipa Ramanathan,
Luisa Hennlein,
Felix Meissner,
Sibylle Jablonka,
Matthias Mann,
Utz Fischer,
Michael Sendtner,
Michael Briese

Affiliations

Changhe Ji: Institute of Clinical Neurobiology, University Hospital Wuerzburg
Jakob Bader: Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry
Pradhipa Ramanathan: Department of Biochemistry, Theodor Boveri Institute, University of Wuerzburg
Luisa Hennlein: Institute of Clinical Neurobiology, University Hospital Wuerzburg
Felix Meissner: Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry
Sibylle Jablonka: Institute of Clinical Neurobiology, University Hospital Wuerzburg
Matthias Mann: Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry
Utz Fischer: Department of Biochemistry, Theodor Boveri Institute, University of Wuerzburg
Michael Sendtner: Institute of Clinical Neurobiology, University Hospital Wuerzburg
Michael Briese: Institute of Clinical Neurobiology, University Hospital Wuerzburg

DOI: https://doi.org/10.1038/s41467-021-21529-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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The noncoding RNA 7SK controls the transcription of mRNAs. Here, the authors show that the 7SK complex interacts with the Smn complex, suggesting crosstalk between transcription and snRNP assembly.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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