Surface-Shaving Proteomics of Mycobacterium marinum Identifies Biofilm Subtype-Specific Changes Affecting Virulence, Tolerance, and Persistence

Kirsi Savijoki; Henna Myllym&#228;ki; Hanna Luukinen; Lauri Paulam&#228;ki; Leena-Maija Vanha-aho; Aleksandra Svorjova; Ilkka Miettinen; Adyary Fallarero; Teemu O. Ihalainen; Jari Yli-Kauhaluoma; Tuula A. Nyman; Mataleena Parikka

doi:10.1128/mSystems.00500-21

mSystems (Jun 2021)

Surface-Shaving Proteomics of Mycobacterium marinum Identifies Biofilm Subtype-Specific Changes Affecting Virulence, Tolerance, and Persistence

Kirsi Savijoki,
Henna Myllymäki,
Hanna Luukinen,
Lauri Paulamäki,
Leena-Maija Vanha-aho,
Aleksandra Svorjova,
Ilkka Miettinen,
Adyary Fallarero,
Teemu O. Ihalainen,
Jari Yli-Kauhaluoma,
Tuula A. Nyman,
Mataleena Parikka

Affiliations

Kirsi Savijoki: Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
Henna Myllymäki: Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Hanna Luukinen: Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Lauri Paulamäki: Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Leena-Maija Vanha-aho: Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Aleksandra Svorjova: Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Ilkka Miettinen: Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
Adyary Fallarero: Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
Teemu O. Ihalainen: Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Jari Yli-Kauhaluoma: Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
Tuula A. Nyman: Institute of Clinical Medicine, Department of Immunology, Rikshospitalet, Oslo University Hospital, Oslo, Norway
Mataleena Parikka: Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland

DOI: https://doi.org/10.1128/mSystems.00500-21
Journal volume & issue: Vol. 6, no. 3

Abstract

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Mycobacteria are naturally resilient, and mycobacterial infections are notoriously difficult to treat with antibiotics, with biofilm formation being the main factor complicating the successful treatment of tuberculosis (TB). The present study shows that nontuberculous Mycobacterium marinum

Published in mSystems

ISSN: 2379-5077 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msystems

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