mSystems
(Jun 2021)
Surface-Shaving Proteomics of Mycobacterium marinum Identifies Biofilm Subtype-Specific Changes Affecting Virulence, Tolerance, and Persistence
Kirsi Savijoki,
Henna Myllymäki,
Hanna Luukinen,
Lauri Paulamäki,
Leena-Maija Vanha-aho,
Aleksandra Svorjova,
Ilkka Miettinen,
Adyary Fallarero,
Teemu O. Ihalainen,
Jari Yli-Kauhaluoma,
Tuula A. Nyman,
Mataleena Parikka
Affiliations
Kirsi Savijoki
Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
Henna Myllymäki
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Hanna Luukinen
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Lauri Paulamäki
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Leena-Maija Vanha-aho
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Aleksandra Svorjova
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Ilkka Miettinen
Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
Adyary Fallarero
Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
Teemu O. Ihalainen
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Jari Yli-Kauhaluoma
Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
Tuula A. Nyman
Institute of Clinical Medicine, Department of Immunology, Rikshospitalet, Oslo University Hospital, Oslo, Norway
Mataleena Parikka
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
DOI
https://doi.org/10.1128/mSystems.00500-21
Journal volume & issue
Vol. 6,
no. 3
Abstract
Read online
Mycobacteria are naturally resilient, and mycobacterial infections are notoriously difficult to treat with antibiotics, with biofilm formation being the main factor complicating the successful treatment of tuberculosis (TB). The present study shows that nontuberculous Mycobacterium marinum
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