Application of Molecularly Imprinted Polymers (MIP) and Flowing Atmospheric-Pressure Afterglow Mass Spectrometry (FAPA-MS) to Analysis of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

Abstract

In recent years, the rapid development of the pharmaceutical industry and the extensive and illicit use of painkillers have led to increased levels of nonsteroidal anti-inflammatory drugs (NSAIDs) in the environment. In view of the significant impact of NSAIDs on living organisms, including humans, their presence in the environment needs to be continuously monitored at trace levels. For this purpose, a combination of molecularly imprinted solid-phase extraction (MISPE) and HPLC-MS analysis is commonly used. MISPE has been utilized in direct, fast, and ecological analysis of drugs using a flowing atmospheric-pressure afterglow ion source for mass spectrometry (FAPA-MS). The new method was applied herein in the determination of naproxen, diclofenac, and ibuprofen. The linear dependence of the intensity of analytical signals on the amount of drugs is in the range of 0.2 μg to 1 g and the method detection limit (MDL) for all drugs is 0.2 μg in environmental samples. The new method also decreased the number of analytical stages, the time and cost of analysis, and the organic solvent consumption, besides being environmentally friendly.

Keywords

• nonsteroidal anti-inflammatory drugs (NSAIDs)
• molecularly imprinted polymers (MIPs)
• flowing atmospheric-pressure afterglow mass spectrometry (FAPA-MS)
• solid-phase extraction (SPE)
• molecularly imprinted solid-phase extraction (MISPE)