Immunological Status of Pregnant Women in Different Trimesters

Abstract

This investigation done to evaluate the immunological status of pregnant women in different trimesters during pregnancy. After performing inclusion and exclusion criteria, this study included 40 pregnant women and 40 healthy women who had married but were not pregnant as a control group. The serum was obtained from pregnant women in three different trimesters and from control group. Interferon γ (IFN-γ), Immunoglobulin-G (IgG) IgA, Rheumatoid factor (RF) and Malondialdehyde (MDA) were measured. The results demonstrate a statistically significant reduction in IFN-γ with respect to the 2nd and 3rd trimesters in comparison to the control group, with no significant change between the control and 1st trimester and a statistical decrease in the 3rd trimester when compared to the 1st trimester. Regarding the total IgG, the result shows a significant decline in the level of IgG in the 1st trimester in comparison to the control group. At the same time, there is a significant elevation in the level of IgG in the 3rd trimester compared to the 2nd trimester. However, there is a significant increase of IgA in the 2nd trimester in comparison to the control group, meanwhile, its level decreases in the 3rd trimester in comparison to 1st and 2nd trimesters. RF increased significantly in the 1st and 2nd trimesters in comparison to the control group, but statistically, there is a significant decrease in 3rd trimester compared to 1st and 2nd trimesters. Finally, the level of MDA increases in all trimesters compared to the control group.

Keywords

• Pregnancy, IFN- γ, IgG, IgA, Rheumatoid factor, MDA.