Different Immunoregulation Roles of Activin A Compared With TGF-β

Fanglin Li; Fanglin Li; Yiru Long; Yiru Long; Xiaolu Yu; Xiaolu Yu; Yongliang Tong; Yongliang Tong; Likun Gong; Likun Gong; Likun Gong

doi:10.3389/fimmu.2022.921366

Frontiers in Immunology (Jun 2022)

Different Immunoregulation Roles of Activin A Compared With TGF-β

Fanglin Li,
Fanglin Li,
Yiru Long,
Yiru Long,
Xiaolu Yu,
Xiaolu Yu,
Yongliang Tong,
Yongliang Tong,
Likun Gong,
Likun Gong,
Likun Gong

Affiliations

Fanglin Li: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
Fanglin Li: University of Chinese Academy of Sciences, Beijing, China
Yiru Long: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
Yiru Long: University of Chinese Academy of Sciences, Beijing, China
Xiaolu Yu: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
Xiaolu Yu: University of Chinese Academy of Sciences, Beijing, China
Yongliang Tong: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
Yongliang Tong: University of Chinese Academy of Sciences, Beijing, China
Likun Gong: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
Likun Gong: University of Chinese Academy of Sciences, Beijing, China
Likun Gong: Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China

DOI: https://doi.org/10.3389/fimmu.2022.921366
Journal volume & issue: Vol. 13

Abstract

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Activin A, a critical member of the transforming growth factor-β (TGF-β) superfamily, is a pluripotent factor involved in allergies, autoimmune diseases, cancers and other diseases with immune disorder. Similar to its family member, TGF-β, activin A also transmits signals through SMAD2/SMAD3, however, they bind to distinct receptors. Recent studies have uncovered that activin A plays a pivotal role in both innate and adaptive immune systems. Here we mainly focus its effects on activation, differentiation, proliferation and function of cells which are indispensable in the immune system and meanwhile make some comparisons with those of TGF-β.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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Abstract

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