Communications Biology (Feb 2021)
Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus
Abstract
Jansson et al. design a high content screening system to target inflammation in human brain cells of the blood–brain barrier (pericytes and endothelial cells) to identify inflammatory modifiers. They identify cardiac glycosides as powerful regulators of neuroinflammatory pathways in brain barrier tissues such as vasculature, meninges and choroid plexus.