Communications Biology (Feb 2021)

Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus

  • Deidre Jansson,
  • Victor Birger Dieriks,
  • Justin Rustenhoven,
  • Leon C. D. Smyth,
  • Emma Scotter,
  • Miranda Aalderink,
  • Sheryl Feng,
  • Rebecca Johnson,
  • Patrick Schweder,
  • Edward Mee,
  • Peter Heppner,
  • Clinton Turner,
  • Maurice Curtis,
  • Richard Faull,
  • Mike Dragunow

DOI
https://doi.org/10.1038/s42003-021-01787-x
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 17

Abstract

Read online

Jansson et al. design a high content screening system to target inflammation in human brain cells of the blood–brain barrier (pericytes and endothelial cells) to identify inflammatory modifiers. They identify cardiac glycosides as powerful regulators of neuroinflammatory pathways in brain barrier tissues such as vasculature, meninges and choroid plexus.