Nature Communications (Mar 2016)

A developmentally regulated switch from stem cells to dedifferentiation for limb muscle regeneration in newts

  • Hibiki Vincent Tanaka,
  • Nathaniel Chuen Yin Ng,
  • Zhan Yang Yu,
  • Martin Miguel Casco-Robles,
  • Fumiaki Maruo,
  • Panagiotis A. Tsonis,
  • Chikafumi Chiba

DOI
https://doi.org/10.1038/ncomms11069
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 8

Abstract

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How limb regeneration in the newt is regulated at a cellular level is much debated. Here, the authors show different mechanisms acting at different developmental stages, namely stem/progenitor cells in larval regeneration and muscle fibres in the blastema regulate limb regeneration after metamorphosis.