Characterization and Topical Study of Aloe Vera Hydrogel on Wound-Healing Process
Karen Zulema Meza-Valle,
Rosa Alicia Saucedo-Acuña,
Karla Lizzette Tovar-Carrillo,
Juan Carlos Cuevas-González,
Erasto Armando Zaragoza-Contreras,
Juana Melgoza-Lozano
Affiliations
Karen Zulema Meza-Valle
Institute of Biomedical Sciences, Autonomous University of Ciudad Juarez, Av. Benjamín Franklin No. 4650, Zona Pronaf Condominio La Plata, Ciudad Juárez 32310, Mexico
Rosa Alicia Saucedo-Acuña
Institute of Biomedical Sciences, Autonomous University of Ciudad Juarez, Av. Benjamín Franklin No. 4650, Zona Pronaf Condominio La Plata, Ciudad Juárez 32310, Mexico
Karla Lizzette Tovar-Carrillo
Institute of Biomedical Sciences, Autonomous University of Ciudad Juarez, Av. Benjamín Franklin No. 4650, Zona Pronaf Condominio La Plata, Ciudad Juárez 32310, Mexico
Juan Carlos Cuevas-González
Institute of Biomedical Sciences, Autonomous University of Ciudad Juarez, Av. Benjamín Franklin No. 4650, Zona Pronaf Condominio La Plata, Ciudad Juárez 32310, Mexico
Erasto Armando Zaragoza-Contreras
Centro de Investigación en Materiales Avanzados, S.C. Miguel de Cervantes No. 120, Complejo Industrial Chihuahua, Chihuahua 31136, Mexico
Juana Melgoza-Lozano
Derseg Co., Abasolo No. 205 Zona Centro, Apaseo el Grande 38160, Mexico
Wound healing is fundamental to restore the tissue integrity. A topical study of the influence of Aloe vera hydrogel, formulated with 1,2-propanediol (propanediol) and triethanolamine (TEA), on the skin wound-healing process was investigated in female Wistar rats. FTIR spectroscopy confirms the presence of carboxylic acid and methyl ester carboxylate groups related with important compounds that confer the hydrogel a good interaction with proteins and growth factors. SEM images show a microstructure and micro-roughness that promote a good adhesion to the wound. Therefore, the swelling kinetics and the contact angle response contribute to the understanding of the in vivo results of the animal test. The results indicated that the Aloe vera hydrogel, prepared with propanediol and TEA, together with its superficial characteristics, improve its rapid penetration without drying out the treated tissue. This produced a positive influence on inflammation, angiogenesis, and wound contraction, reducing 29% the total healing time, reaching the total closure of the wound in 15 days.
