Nature Communications (Dec 2021)
Live tumor imaging shows macrophage induction and TMEM-mediated enrichment of cancer stem cells during metastatic dissemination
- Ved P. Sharma,
- Binwu Tang,
- Yarong Wang,
- Camille L. Duran,
- George S. Karagiannis,
- Emily A. Xue,
- David Entenberg,
- Lucia Borriello,
- Anouchka Coste,
- Robert J. Eddy,
- Gina Kim,
- Xianjun Ye,
- Joan G. Jones,
- Eli Grunblatt,
- Nathan Agi,
- Sweta Roy,
- Gargi Bandyopadhyaya,
- Esther Adler,
- Chinmay R. Surve,
- Dominic Esposito,
- Sumanta Goswami,
- Jeffrey E. Segall,
- Wenjun Guo,
- John S. Condeelis,
- Lalage M. Wakefield,
- Maja H. Oktay
Affiliations
- Ved P. Sharma
- Department of Anatomy and Structural Biology, Albert Einstein College of Medicine
- Binwu Tang
- Laboratory of Cancer Biology and Genetics, National Cancer Institute
- Yarong Wang
- Department of Anatomy and Structural Biology, Albert Einstein College of Medicine
- Camille L. Duran
- Department of Anatomy and Structural Biology, Albert Einstein College of Medicine
- George S. Karagiannis
- Department of Anatomy and Structural Biology, Albert Einstein College of Medicine
- Emily A. Xue
- Department of Anatomy and Structural Biology, Albert Einstein College of Medicine
- David Entenberg
- Department of Anatomy and Structural Biology, Albert Einstein College of Medicine
- Lucia Borriello
- Department of Anatomy and Structural Biology, Albert Einstein College of Medicine
- Anouchka Coste
- Department of Anatomy and Structural Biology, Albert Einstein College of Medicine
- Robert J. Eddy
- Department of Anatomy and Structural Biology, Albert Einstein College of Medicine
- Gina Kim
- Department of Anatomy and Structural Biology, Albert Einstein College of Medicine
- Xianjun Ye
- Department of Anatomy and Structural Biology, Albert Einstein College of Medicine
- Joan G. Jones
- Department of Anatomy and Structural Biology, Albert Einstein College of Medicine
- Eli Grunblatt
- Department of Biology, Yeshiva University
- Nathan Agi
- Department of Biology, Yeshiva University
- Sweta Roy
- Department of Biology, Yeshiva University
- Gargi Bandyopadhyaya
- Department of Biology, Yeshiva University
- Esther Adler
- Department of Pathology, NYU Langone Medical Center
- Chinmay R. Surve
- Department of Anatomy and Structural Biology, Albert Einstein College of Medicine
- Dominic Esposito
- Protein Expression Laboratory, Frederick National Laboratory for Cancer Research
- Sumanta Goswami
- Department of Anatomy and Structural Biology, Albert Einstein College of Medicine
- Jeffrey E. Segall
- Department of Anatomy and Structural Biology, Albert Einstein College of Medicine
- Wenjun Guo
- Department of Cell Biology, Albert Einstein College of Medicine
- John S. Condeelis
- Department of Anatomy and Structural Biology, Albert Einstein College of Medicine
- Lalage M. Wakefield
- Laboratory of Cancer Biology and Genetics, National Cancer Institute
- Maja H. Oktay
- Department of Anatomy and Structural Biology, Albert Einstein College of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-27308-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 24
Abstract
Intravital imaging reveals macrophage-driven de novo induction of cancer stem cells in vivo, and their dramatic enrichment on dissemination through TMEM doorways. These findings provide a mechanism for the validated ability of TMEM doorway density to be prognostic for distant recurrence of metastatic tumors in breast cancer patients.
