Successful management with urgent haploidentical‐peripheral blood stem cell transplantation for a patient with severe aplastic anaemia who developed disseminated fungal infection following immunosuppressive therapy
Norihito Ikenobe,
Kentaro Fujimori,
Yoshihiro Gocho,
Shota Myojin,
Masaki Yamada,
Kenichi Imadome,
Mikiko Miyasaka,
Osamu Miyazaki,
Akihiro Yoneda,
Shotaro Matsumoto,
Satoshi Nakagawa,
Takao Deguchi,
Akihiro Iguchi,
Daisuke Tomizawa,
Chikara Ogimi,
Kimikazu Matsumoto,
Hirotoshi Sakaguchi
Affiliations
Norihito Ikenobe
Children's Cancer CenterNational Center for Child Health and DevelopmentTokyo Japan
Kentaro Fujimori
Children's Cancer CenterNational Center for Child Health and DevelopmentTokyo Japan
Yoshihiro Gocho
Children's Cancer CenterNational Center for Child Health and DevelopmentTokyo Japan
Shota Myojin
Department of Medical SubspecialtiesDivision of Infectious DiseasesNational Center for Child Health and DevelopmentTokyo Japan
Masaki Yamada
Department of Medical SubspecialtiesDivision of Infectious DiseasesNational Center for Child Health and DevelopmentTokyo Japan
Kenichi Imadome
Department of Advanced Medicine for Viral InfectionsNational Center for Child Health and DevelopmentTokyo Japan
Mikiko Miyasaka
Department of RadiologyNational Center for Child Health and DevelopmentTokyo Japan
Osamu Miyazaki
Department of RadiologyNational Center for Child Health and DevelopmentTokyo Japan
Akihiro Yoneda
Department of Surgical SpecialtiesDivision of SurgeryNational Center for Child Health and DevelopmentTokyo Japan
Shotaro Matsumoto
Critical Care MedicineNational Center for Child Health and DevelopmentTokyo Japan
Satoshi Nakagawa
Critical Care MedicineNational Center for Child Health and DevelopmentTokyo Japan
Takao Deguchi
Children's Cancer CenterNational Center for Child Health and DevelopmentTokyo Japan
Akihiro Iguchi
Children's Cancer CenterNational Center for Child Health and DevelopmentTokyo Japan
Daisuke Tomizawa
Children's Cancer CenterNational Center for Child Health and DevelopmentTokyo Japan
Chikara Ogimi
Department of Medical SubspecialtiesDivision of Infectious DiseasesNational Center for Child Health and DevelopmentTokyo Japan
Kimikazu Matsumoto
Children's Cancer CenterNational Center for Child Health and DevelopmentTokyo Japan
Hirotoshi Sakaguchi
Children's Cancer CenterNational Center for Child Health and DevelopmentTokyo Japan
Abstract Urgent haploidentical haematopoietic cell transplantation may be considered in cases of severe aplastic anaemia (SAA) without a human leukocyte antigen‐matched donor and suffering from severe infection. However, deciding on allogeneic transplantation in the setting of active systemic infection is challenging due to poor outcomes. This report presents a case of disseminated Magnusiomyces capitatus infection in a 5‐year‐old male who underwent immunosuppressive therapy for hepatitis‐associated SAA. To address the critical situation, granulocyte transfusion was promptly administered from the patient's mother, followed by unmanipulated haploidentical peripheral blood stem cell transplantation from the patient's father with posttransplant cyclophosphamide, ultimately resulting in successful rescue.
