Real-World Evaluation of Quality of Life, Effectiveness, and Safety of Aflibercept Plus FOLFIRI in Patients with Metastatic Colorectal Cancer: The Prospective QoLiTrap Study

Ralf-Dieter Hofheinz; Sandro Anchisi; Birgit Grünberger; Hans G. Derigs; Mark-Oliver Zahn; Christine Geffriaud-Ricouard; Max Gueldner; Christine Windemuth-Kieselbach; Stefanie Pederiva; Pierre Bohanes; Felicitas Scholten; Gudrun Piringer; Josef Thaler; Roger von Moos

doi:10.3390/cancers14143522

Cancers (Jul 2022)

Real-World Evaluation of Quality of Life, Effectiveness, and Safety of Aflibercept Plus FOLFIRI in Patients with Metastatic Colorectal Cancer: The Prospective QoLiTrap Study

Ralf-Dieter Hofheinz,
Sandro Anchisi,
Birgit Grünberger,
Hans G. Derigs,
Mark-Oliver Zahn,
Christine Geffriaud-Ricouard,
Max Gueldner,
Christine Windemuth-Kieselbach,
Stefanie Pederiva,
Pierre Bohanes,
Felicitas Scholten,
Gudrun Piringer,
Josef Thaler,
Roger von Moos

Affiliations

Ralf-Dieter Hofheinz: Department of Oncology, University Hospital Mannheim, Theodor-Kutzer-Ufer 1, 68167 Mannheim, Germany
Sandro Anchisi: Department of Oncology, Valais Romand Hospital Center, Valais Hospital, Av. Grand-Champsec 86, 1951 Sion, Switzerland
Birgit Grünberger: Department of Internal Medicine, Hematology and Oncology, Hospital Wiener Neustadt, Corvinusring 3-5, 2700 Wiener Neustadt, Austria
Hans G. Derigs: Department of Internal Medicine 3, Hematology, Oncology, Palliative Medicine and Pneumology, Frankfurt Höchst Clinic, Gotenstrasse 6-8, 65929 Frankfurt am Main, Germany
Mark-Oliver Zahn: Department of Internal Medicine, Hematology and Oncology, MVZ Oncology Cooperation Harz, Kosliner Str. 14, 38642 Goslar, Germany
Christine Geffriaud-Ricouard: Sanofi, Global Medical Oncology, 54 Rue La Boetie, 75008 Paris, France
Max Gueldner: Sanofi, Potsdamer Str. 8, 10785 Berlin, Germany
Christine Windemuth-Kieselbach: Department of Biometry, Alcedis, Winchesterstr 3, 35394 Giessen, Germany
Stefanie Pederiva: Center for Oncology and Hematology, Cantonal Hospital, Im Ergel, 5404 Baden, Switzerland
Pierre Bohanes: Department of Oncology and Internal Medicine, Center for Chemotherapy, 1004 Lausanne, Switzerland
Felicitas Scholten: Department of Internal Medicine 3, Hematology, Oncology, Palliative Medicine and Pneumology, Frankfurt Höchst Clinic, Gotenstrasse 6-8, 65929 Frankfurt am Main, Germany
Gudrun Piringer: Department of Internal Medicine IV, Wels-Grieskirchen Hospital, Grieskirchner Str. 42, 4600 Wels, Austria
Josef Thaler: Department of Internal Medicine IV, Wels-Grieskirchen Hospital, Grieskirchner Str. 42, 4600 Wels, Austria
Roger von Moos: Department of Oncology, Cantonal Hospital Graubuenden, Loestrasse 170, 7000 Chur, Switzerland

DOI: https://doi.org/10.3390/cancers14143522
Journal volume & issue: Vol. 14, no. 14
p. 3522

Abstract

Read online

Aflibercept plus FOLFIRI prolongs overall survival (OS) in patients with metastatic colorectal cancer after the failure of oxaliplatin-containing therapy. QoLiTrap prospectively evaluated the quality of life (QoL) and effectiveness of this regimen in daily clinical practice, according to RAS status, sex, and prior targeted therapy, especially epidermal growth factor receptor inhibitors (EGFR-I). The primary endpoint was the percentage of patients whose EORTC QLQ-C30 global health status (GHS) improved or reduced by RAS status, and prior EGFR-I therapy.

Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

About the journal

Abstract

Keywords