Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease

Nicholas F. Fitz; Kyong Nyon Nam; Cody M. Wolfe; Florent Letronne; Brittany E. Playso; Bistra E. Iordanova; Takashi D. Y. Kozai; Richard J. Biedrzycki; Valerian E. Kagan; Yulia Y. Tyurina; Xianlin Han; Iliya Lefterov; Radosveta Koldamova

doi:10.1038/s41467-021-23762-0

Nature Communications (Jun 2021)

Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease

Nicholas F. Fitz,
Kyong Nyon Nam,
Cody M. Wolfe,
Florent Letronne,
Brittany E. Playso,
Bistra E. Iordanova,
Takashi D. Y. Kozai,
Richard J. Biedrzycki,
Valerian E. Kagan,
Yulia Y. Tyurina,
Xianlin Han,
Iliya Lefterov,
Radosveta Koldamova

Affiliations

Nicholas F. Fitz: Deparment of Environmental and Occupational Health, University of Pittsburgh
Kyong Nyon Nam: Deparment of Environmental and Occupational Health, University of Pittsburgh
Cody M. Wolfe: Deparment of Environmental and Occupational Health, University of Pittsburgh
Florent Letronne: Deparment of Environmental and Occupational Health, University of Pittsburgh
Brittany E. Playso: Deparment of Environmental and Occupational Health, University of Pittsburgh
Bistra E. Iordanova: Department of Bioengineering, University of Pittsburgh
Takashi D. Y. Kozai: Department of Bioengineering, University of Pittsburgh
Richard J. Biedrzycki: Deparment of Environmental and Occupational Health, University of Pittsburgh
Valerian E. Kagan: Deparment of Environmental and Occupational Health, University of Pittsburgh
Yulia Y. Tyurina: Deparment of Environmental and Occupational Health, University of Pittsburgh
Xianlin Han: Barshop Institute for Longevity and Aging Studies
Iliya Lefterov: Deparment of Environmental and Occupational Health, University of Pittsburgh
Radosveta Koldamova: Deparment of Environmental and Occupational Health, University of Pittsburgh

DOI: https://doi.org/10.1038/s41467-021-23762-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 18

Abstract

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Microglia can clear amyloid plaques in Alzheimer’s disease. Here, the authors show that specific isoforms of the phospholipid forming APOE lipoproteins activate microglia in pre-clinical mouse models of Alzheimer’s disease.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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