Frontiers in Aging Neuroscience (Dec 2021)
An Update on Antioxidative Stress Therapy Research for Early Brain Injury After Subarachnoid Hemorrhage
- Fa Lin,
- Fa Lin,
- Fa Lin,
- Fa Lin,
- Runting Li,
- Runting Li,
- Runting Li,
- Runting Li,
- Wen-Jun Tu,
- Wen-Jun Tu,
- Wen-Jun Tu,
- Yu Chen,
- Yu Chen,
- Yu Chen,
- Yu Chen,
- Ke Wang,
- Ke Wang,
- Ke Wang,
- Ke Wang,
- Xiaolin Chen,
- Xiaolin Chen,
- Xiaolin Chen,
- Xiaolin Chen,
- Jizong Zhao,
- Jizong Zhao,
- Jizong Zhao,
- Jizong Zhao,
- Jizong Zhao
Affiliations
- Fa Lin
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Fa Lin
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Fa Lin
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Fa Lin
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Runting Li
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Runting Li
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Runting Li
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Runting Li
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Wen-Jun Tu
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Wen-Jun Tu
- The General Office of Stroke Prevention Project Committee, National Health Commission of the People’s Republic of China, Beijing, China
- Wen-Jun Tu
- Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, China
- Yu Chen
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yu Chen
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Yu Chen
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Yu Chen
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Ke Wang
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Ke Wang
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Ke Wang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Ke Wang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Xiaolin Chen
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Xiaolin Chen
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Xiaolin Chen
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Xiaolin Chen
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Jizong Zhao
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Jizong Zhao
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Jizong Zhao
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Jizong Zhao
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Jizong Zhao
- Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China
- DOI
- https://doi.org/10.3389/fnagi.2021.772036
- Journal volume & issue
-
Vol. 13
Abstract
The main reasons for disability and death in aneurysmal subarachnoid hemorrhage (aSAH) may be early brain injury (EBI) and delayed cerebral ischemia (DCI). Despite studies reporting and progressing when DCI is well-treated clinically, the prognosis is not well-improved. According to the present situation, we regard EBI as the main target of future studies, and one of the key phenotype-oxidative stresses may be called for attention in EBI after laboratory subarachnoid hemorrhage (SAH). We summarized the research progress and updated the literature that has been published about the relationship between experimental and clinical SAH-induced EBI and oxidative stress (OS) in PubMed from January 2016 to June 2021. Many signaling pathways are related to the mechanism of OS in EBI after SAH. Several antioxidative stress drugs were studied and showed a protective response against EBI after SAH. The systematical study of antioxidative stress in EBI after laboratory and clinical SAH may supply us with new therapies about SAH.
Keywords
- oxidative stress
- subarachnoid hemorrhage
- early brain injury
- delayed cerebral ischemia
- experimental – animal models
